Calais to Combloux is 560 miles by autoroute, i.e. 7½ hours driving plus stops. The total cost of tolls is about SD_tollsC€ each way.
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If you are setting your satnav, our address is 2999 route de Vernay, Combloux (but heed our warnings about satnav directions - do not stray off the D1212 Albertville road out of Sallanches).
The A26 autoroute runs direct from Calais docks, or from the tunnel turn right onto the A16 and right again just after junction 46.
(Fuel is much cheaper at Supermarkets so from junc 46 we often pop into Calais: 1km to the Carrefour).
After about 40 kms you pick up a ticket at the Péage (toll), you pay at the station just before Reims (275 kms from Calais). You can pay tolls automatically by UK credit cards through certain (left hand) gates.
Keep straight on for about 10kms, and keep left at the fork and pick up a ticket at the next toll on the new autoroute that by-passes the city.
(Unless you want to visit Reims, to get petrol or find a motel. In that case, take exit 26 off the A4 to the Tinqueux district. You can continue on the A4 towards Metz to pick up a Péage ticket 5 kms out of Reims and rejoin the by-pass.)
About 26 kms past Reims, turn right through Champagne country towards Troyes (back on the A26), where you'll link into the A5 towards Dijon - which in turn joins into the A31 at Langres. Reims to Dijon is 280 kms.
Look out for the Geneva exit near Dijon. This is the A39, through the Juras to Bourg en Bresse. (In summer, you may prefer to take a more scenic route on the N roads through the Juras and down into Geneva). Dijon to Bourg is about 100km. Just before Bourg the A39 joins into the A40.
This is a good area for an overnight stop because it is only about 160 kms from Bourg to Combloux.
Watch out for the right turn towards Geneva about 25 kms after joining the A40. Then you climb through the mountains, with spectacular views and viaducts and four tunnels in the 78 kms to the next toll gate - which costs about 42 euros. From here the road descends towards Geneva, and joins into the route from Geneva towards Chamonix. You will be taking exit 20 through Sallanches.